ShandongEyeInstitute,aprofessionalinstitutionintegratingscientificresearch,teaching,medicaltreatmentandblindnessprevention,wasestablishedinQingdaoinJanuary1991withtheapprovaloftheformerNationalScienceandTechnologyCommission.AffiliatedtoShandongFirstMedicalUniversity(ShandongAcademyofMedicalSciences),ithasfournational-levelplatforms,includingtheNationalClinicalKeySpecialtyConstructionUnitoftheNationalHealthCommission,theNationalKeyDisciplineJointConstructionUnitoftheMinistryofEducation,theStateKeyLaboratoryCultivationBaseCo-constructedbyShandongProvinceandtheMinistryofScienceandTechnology,andtheNationalDrugClinicalTrialInstitutionoftheStateFoodandDrugAdminist
Accordingtoourownadvantages,StateKeyLaboratoryCultivationBase,ShandongProvincialKeyLaboratoryofOphthalmology,focusesonthemainclinicalneedsandthedevelopmenttrendofblindingeyediseasetosolvetheproblemsofcornealdisease,childrenandinfantscataract,preventionandfunctionalreconstructionofoculartrauma.Wehavemadegoodachievementsinthefieldsofinfectiouskeratopathy,cornealinnovationsurgery,tissueengineeringconjunctiva,systemicdiseasesoftheeyes,andinfantcataract.Over1,000academicpapershavebeenpublished,amongwhichmorethan300papersarepublishedinAdvancedFunctionalMaterial,PNAS,Ophthalmology,Diabetes,StemCellsandotherSCIjournals.Forty-sevenauthorizedpatentshavebeenobtained,fi
1.Asthepersonincharge,IundertaketheprojectofQingdaopublicdomainscienceandtechnologysupportplan:TheRoleandMechanismofMastCellsinRepairingDiabeticCornealDamage.Fundnumber:19-6-1-24-nsh,2019.06-2021.06;100,000yuan,underresearch.2.Asthepersonincharge,IundertaketheoutstandingyoungtalentssupportplanofShandongEyeInstitute,2019.1-2020.12;300,000yuan,underresearch.3.Asthepersonincharge,IundertakeNaturalScienceFoundationofShandongProvince:TheMechanismofBoneMarrowMesenchymalStemSellsPromotingTheRepairmentofCornealEpithelialInjuryinDiabeticMiceThroughTSG-6.Fundnumber:ZR2016HP14,50,000yuan,2016.11-2018.6,finished.4.Asthepersonincharge,IundertakeQingdaoAppliedBasicResearc
Biomechanicsandrefractiveplatformsarenewlyestablishedresearchdirections.Someachievementshavebeenmadedinrelatedresearch.Theresearchdirectionsoftheplatforminclude:1.Theinfluencesthatvarioustypesofcornealsurgeries(suchascornealrefractivesurgeryandcornealtransplantsurgery)haveontherefractivecharacteristicsofcornealtissueaswellaschangesinpostoperativevisualquality;2.Basedontheexistingfemtosecondlasertechnologyandexcimerlasertechnology,weactivelyexpandfemtosecondlasertoassistvarioustypesofcornealtransplantationoperations,includinglamellarcornealtransplantation,penetratingcornealtransplantation,cornealendothelialtransplantationsurgery,etc,andmakefulluseofexcimerlas
TheanimalexperimentcenterofShandongEyeInstitutewasformallyestablishedinJune2002.Afterseveralyearsofdevelopment,theareahasincreasedfrommorethan100squaremetersto435squaremetersinJune2006.Theexperimentalanimalcenterhasawealthofanimalfeedingequipmentandanimalexperimentalinstruments.IthasdevelopedfromthegenerallevelenvironmentofanimalfeedingtotheSPFlevelwhichmeetsthenationalpurificationstandard.Theexperimentalanimalcenterisspecificallydividedintothreecleanrabbitfeedingrooms,fourSPFmicefeedingrooms,twostandardoperatinglaboratoriesandonenegativepressureoperatinglaboratory.Theenvironmentalconditionsmeettherequirementsofbarrierfacilities,andithas20EVC(centralcagevent
InheritedEyeDiseasesResearchPlatformisaffiliatedtotheStateKeyLaboratoryCultivationBase,ShandongProvincialKeyLaboratoryofOphthalmology.Theplatformisestablishedtoenhanceourunderstandingofthepathogenesisandtofacilitatethetranslationalresearchoftheinheritedeyediseases.Ourstudyinterestscovermultipleeyediseases,includingcornealdystrophy,keratoconus,cataract,age-relatedmaculardegeneration.Theplatformisequippedwithlarge-scalesamplestoragefacilitiesandstate-of-the-artexperimentalequipment,andisreadilytocarryouthigh-standardresearchprojects.TheplatformmembershostthreeNationalNaturalScienceFoundationsandhavepublished13SCIpaperongenetic-relatedeyediseases.1.Functionalch
LaboratoryofBiomaterialandOphthalmicDrugisaffiliatedtotheStateKeyLaboratoryCultivationBase,ShandongProvincialKeyLaboratoryofOphthalmology.Ourresearchfocusesontheapplicationandbasicresearchofbiomaterialsandophthalmicdrugs,whichiscarriedoutinthefollowingtwoaspects:(1)synthesis,characterizationofbiomaterialsandtheirapplicationsinophthalmicdrugdelivery;(2)qualitativeandquantitativeanalysisofsmallmoleculesinophthalmicsamples.Theplatformisequippedwithhighperformanceliquidchromatographytandemmassspectrometer,high-performanceliquidchromatography,highspeedcentrifugerandsomeotherequipments,whichcanmeettheneedsforbiomaterialsandophthalmicdrugresearches.LaboratoryofBiom
Thelaboratoryofpathogenicbiologyhasbeenestablishedsince2007withemphasisonthefollowingaspects:（1)interactionbetweencommonophthalmicpathogenicmicroorganismsandcornealcells;(2)biologicalcontrolofinfectiousophthalmopathy.Uptonow,ithaspresidedoverseveralprojectsoftheNationalNaturalScienceFoundation,ShandongYouthFoundation,ShandongMedicalCollegeandmanyprojectsofShandonginstituteofophthalmology,andparticipatedinanational"973"preliminaryprojectandotherthreenationalnaturalsciencefundsasmaincompletedpersonnel.Significantprogresshasbeenmadeinthemoleculardiagnosisandbiologicalcontrolofinfectiouskeratopathy.Atpresent,over10SCIpapers,morethan5domesticcorejournalpapershav
Ourplatformisinterestedinthepathologicalmechanismandtranslationalresearchofimmune-relatedophthalmopathy.Thecurrentresearchworkmainlyfocusedon:(1)Understandingtheimmunologicalmechanismofinflammatorydiseasesanddiabeticeyedisease;(2)Immunologicalmechanismandclinicaltranslationofdiabeticcornealneuropathy;(3)Thepathogenesisandclinicaltranslationalresearchofcornealallograftrejection.Ourteamconsistsof1researcher,1associateresearcher,3assistantresearcher,and11masteranddoctoralstudents.Theplatformisequippedwithflowcytometry,laserconfocalmicroscope,multi-functionalmicroplatereader,ultra-high-speedcentrifuge,andvacuumfreezedrier.Atpresent,theplatformundertakesanumberof
Inrecentyears,thelaboratorycontinuestoupdatethecellplatformequipments,innovativecellresearchtechnology.Theexperimentaltechniquesofcellbiologyincludeprimarycellandcelllineculture,passage,cryopreservationandresuscitation;Microscopicobservationandanalysisofcells(optical,fluorescence);Flowcytometrysortingtechniques,andsoon.Atpresent,theequipmentsruncontinuously,andareopen.Laboratoryequipment:MVEliquidnitrogentank,bio-radcellcounter,NUAIREbiosafetycabinet,Thermoincubator,BDFACSAriaIIIflowcytometer,NIKONC1PLUSlaserconfocalmicroscope,GMPcellcultureroom,andsoon.
