The laboratory of pathogenic biology has been established since 2007 with emphasis on the following aspects:（1) interaction between common ophthalmic pathogenic microorganisms and corneal cells; (2) biological control of infectious ophthalmopathy.

Up to now, it has presided over several projects of the National Natural Science Foundation, Shandong Youth Foundation, Shandong Medical College and many projects of Shandong institute of ophthalmology, and participated in a national "973" preliminary project and other three national natural science funds as main completed personnel. Significant progress has been made in the molecular diagnosis and biological control of infectious keratopathy. At present, over 10 SCI papers, more than 5 domestic core journal papers have been published, 7 international and domestic invention patents have been applied for, and 2 have been authorized; “Pathogenic detection and epidemiological study of infectious ophthalmopathy” has obtained the second prize of scientific and technological achievement of Shandong Medical College in 2012.

This laboratory was converted into a Class II Biosafety Laboratory (BSL-2) since 2012 and there are two assistant researchers currently. The laboratory is equipped with many precision instruments, such as biosafety cabinet, autoclave, CO2 incubator, fluorescent microscope and ultra-low temperature refrigerator and so on.

Representative Publications：

Tian X, Wang T, Zhang S, Wang Q, Hu X, Ge C, Xie L,* Zhou Q.* PEDF reduces the severity of herpetic simplex keratitis in mice. Invest Ophthalmol Vis Sci. 2018;59:2923-2931.

Yuan Q, Wu Y, Wang Y, Chen L, Qu M, Duan K, Zhao G.* Protective efficacy of a peptide derived from a potential adhesin of Pseudomonas aeruginosa against corneal infection. Exp Eye Res. 2016 Feb;143:39-48.

Zhao G, Chen M, Liu T, Sun SY, Zhao J, Xie LX*.Association of HSV-1 antigen distribution in the cornea with clinical characteristics of herpetic stromal keratitis. Eur J Ophthalmol. 2012;22:S40-45.

Xie L*, Zhai H, Shi W, Zhao J, Sun S, Zang X. Hyphal growth patterns and recurrence of fungal keratitis after lamellar keratoplasty. Ophthalmology. 2008;115:983-987.

Xie L*, Hu J, Shi W. Treatment failure after lamellar keratoplasty for fungal keratitis. Ophthalmology. 2008;115:33-36.

Shi W, Chen M, Xie L*. Amniotic membrane transplantation combined with antiviral and steroid therapy for herpes necrotizing stromal keratitis. Ophthalmology. 2007;114:1476-1481.

Xie L, Zhong W，Shi W, Sun S. Spectrum of Fungal Keratitis in North China. Ophthalmology. 2006;113(11):1943-1948.